Explore the Protein Landscape of Life
Proteomics reveals the proteins that drive biological systems, connecting genetic information with molecular function through protein identification, quantification, structural analysis, interactions and post-translational modifications.
What is Proteomics?
Proteomics is the large-scale study of proteins within a biological system. It investigates protein abundance, structure, function, interactions, modifications and dynamics to provide a functional view of molecular biology.
From Genetic Information
to Functional Biology
Genomics describes the genetic blueprint, while transcriptomics examines RNA expression. Proteomics adds another important layer by measuring the proteins that perform many of the molecular functions within cells.
Protein Expression
Measure and compare protein abundance across samples, experimental conditions and biological systems.
Protein Structure
Investigate protein architecture, molecular domains, structural changes and binding interactions.
Protein Interactions
Explore protein–protein interactions and molecular complexes involved in cellular processes.
Major Areas of Proteomics
Structural Proteomics
Structural proteomics investigates the three-dimensional architecture of proteins and molecular complexes using approaches such as X-ray crystallography, NMR spectroscopy, cryo-electron microscopy and computational analysis.
Expression Proteomics
Expression proteomics focuses on protein abundance and changes between biological samples. Mass spectrometry, 2D-PAGE and quantitative approaches are widely used.
Interaction Proteomics
Interaction proteomics studies protein–protein interactions and molecular complexes using affinity purification, mass spectrometry and interaction mapping.
Quantitative Proteomics
Quantitative proteomics measures relative or absolute protein abundance to identify molecular changes across experimental conditions.
From Sample to Protein Insights
Modern proteomics combines experimental workflows with analytical technologies and bioinformatics to transform complex biological samples into meaningful protein-level information.
Sample Preparation
Protein Extraction
Peptide Preparation
Mass Spectrometry
Protein Identification
Bioinformatics
Mass Spectrometry in Proteomics
Mass spectrometry has become one of the central technologies in modern proteomics. Protein samples can be enzymatically digested into peptides, measured according to their mass-to-charge ratios, and analyzed using peptide fragmentation and sequence databases.
Protein Identification
Identify proteins by matching measured peptide information with protein sequence databases.
Quantitative Analysis
Compare protein abundance across samples using label-free or labeling-based quantitative strategies.
PTM Analysis
Investigate phosphorylation, acetylation, methylation, glycosylation and other post-translational modifications.
Connecting Multiple Molecular Layers
Proteomics can be integrated with genomics, transcriptomics and metabolomics to create a more comprehensive view of biological systems.
The Future of Proteomics
Explore the World of Proteomics
Discover technologies, reagents, consumables and resources supporting protein research, proteome analysis and mass spectrometry workflows.
Explore Products